The 93rd Annual Meeting of the Japanese Pharmacological SocietyThe 93rd Annual Meeting of the Japanese Pharmacological Society

Program

Program at a Glance

Plenary Lecture

  • Pharmacological control of regulatory T cells in immunological diseases

    Shimon Sakaguchi (Osaka University)
    web site

Special Lectures

Special Lecture 1

  • Toward the Mysteries of Sleep

    Masashi Yanagisawa (University of Tsukuba)
    web site

Special Lecture 2

  • Role of transporter sciences in new drug discovery and development.

    Yuichi Sugiyama (RIKEN)
    web site

Special Lecture 3

  • The activation mechanism and drug discovery of G protein-coupled receptor.

    Shuguang Yuan (Research Center for Computer-Aided Drug Discovery Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences)
    web site

Special Lecture 4

  • Biological roles of ATP receptors and microglia: Pharmacologists are essential for drug discovery

    Kazuhide Inoue (Kyushu University)
    web site

Special Lecture 5

  • Harnessing gut commensals to combat disease

    Kenya Honda (Keio University)
    web site

Special Lecture 6

  • CryoEM of GPCRs: from molecular mechanism to drug discovery

    Georgios Skiniotis (Stanford University, USA)
    web site

Special Lecture 7

  • Spying on neuromodulation by constructing new genetically encoded fluorescent sensors

    Yulong Li (Peking University)
    web site

Special Lecture 8

  • Synaptic Plasticity: from bench to bedside

    Takuya Takahashi (Yokohama City University)
    web site

Special Lecture 9

  • Resolvins & Pro-Resolving Mediators with Novel Mechanisms in Infectious-Inflammation

    Charles N Serhan (Harvard University, USA)
    web site

Special Lecture 10

  • A Chemical Approach to Controlling Cell Fate

    Sheng Ding (University of California, San Francisco, USA)
    web site

Annual Meeting Symposia

JPS-ASCEPT Lecture

  • The structural basis of peptide GPCR activation and signalling.

    Denise Wootten(Monash Institute of Pharmaceutical Sciences, Monash University, Australia)
    web site

Evaluation of drug safety and efficacy by clinical epidemiology utilizing large scale medical databases including real world data

Chairs: Koji Kawakami (Kyoto University)
Satoshi Asai (Nihon University)
How to select appropriate medical real world database to meet your research question
Koji Kawakami (Kyoto University)
Clinical epidemiological and pharmacoepidemiological studies using the Diagnosis Procedure Combination database.
Taisuke Jo (The University of Tokyo)
Descriptive epidemiology of prescriptions of drugs listed in Screening Tool for Older Person’s appropriate Prescriptions in Japanese (STOPP-J) in older adults: results from National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB)
Yosuke Yamamoto (Kyoto University)
Challenge to the future life with Real World Data
Hironobu Tokumasu (Kurashiki Clinical Research Institute)

The use of clinical big data on pharmacological studies : from hypothesis validation to drug repositioning

Chairs: Keisuke Ishizawa (Tokushima University)
Takayuki Nakagawa (Kyoto University Hospital)
Pharmacological research development based on medical big data (disease name, Lab tests, medication, etc.) of 2 million patients at Nihon University Hospital for 15 years
Satoshi Asai (Nihon University)
Pharmacological study by bidirectional approach between bench and bedside: novel evidence from risk factor analysis in cancer patients undergoing chemotherapy
Atsufumi Kawabata (Kindai University)
Approach to drug discovery integrating large-scale medical information databases with clinical and basic research
Mitsuhiro Goda (Tokushima University Hospital)
The impact of hypothesis and prediction in data-driven pharmacological studies
Shuji Kaneko (Kyoto University)

Symposia/Workshops

Molecular basis of neuron-neuron and neuron-non neuronal cell communication in health and disease
Chairs: Naoya Yamashita (Juntendo University)
Tetsuya Takano (Duke University)
Regulation of anterograde transcytosis of neurotrophin receptors and its role in health and diseases
Naoya Yamashita (Juntendo University)
Neuronal Signaling in Islet Development and Function
Rejji Kuruvilla (Johns Hopkins University)
InSyn1 regulates GABAergic inhibition via the dystroglycan complex and is required for cognitive behaviors in mice
Akiyoshi Uezu (CasTag Biosciences Inc./ The Departments of Cell Biology, Duke University Medical School)
Chemico-genetic discovery of molecules underlying tripartite-synaptic function in vivo
Tetsuya Takano (Duke University Medical School)

Pharmacology education for nurses: based on establishing the “Model Core Curriculum for Nursing Science Education in Japan” and revision of “Regulation for Enforcement of the Act on Public Health Nurses, Midwives, and Nurses”
Chairs: Toshihiko Yanagita (University Miyazaki)
Tomoko Akase (Yokohama City University)
Activation of the nursing education through utilizing revision of Rules for Designation of Public Health Nurse, Midwife and Nurse Schools and Training Schools among nursing universities in Japan
Yukari Sugita (Ministry of Education, Culture, Sports, Science and Technology)
A message from clinical nursing: What to ask for pharmacology education for safe medication
Chieko Komiyama (The University of Tokyo Hospital)
The latest midwifery education on pharmacology during pregnancy, childbirth, postpartum and breastfeeding period
Masumi Imura (Japanese Red Cross College of Nursing)
Pharmacology education at university:To train nurses to gain expertise in drug treatment
Tomoko Akase (Yokohama City University)

The current situation in genomic medicine and peptide drug discovery and their applications to unmet needs in the field of cardiovascular health
Chairs: Kouichi Tamura (Yokohama City University)
Manabu Minami (Kyoto University Hospital)
Trans-layer omics analysis, disease biology, and drug discovery
Yukinori Okada (Osaka University)
Revolutionary therapeutic peptides
Hiroaki Suga (The University of Tokyo)
Sterile inflammation and inflammasome in cardiovascular medicine: current status and prospects of therapy
Masafumi Takahashi (Jichi Medical University)

Current situation of behavioral test for experimental animal in pharmacology
Chairs: Takahisa Murata (The University of Tokyo)
Kazuya Miyagawa (International University of Health and Welfar)
Evaluation of emotional behavior characteristics of stress-adaptive and -maladaptive mice
Kazuya Miyagawa (International University of Health and Welfare)
Animal models in addiction research
Soichiro Ide (Tokyo Metropolitan Institute of Medical Science)
Examples of animal behavior assessment tools developed through academic-industrial collaborations.
Hitoshi Takahashi (Muromachi Kikai Co., Ltd)
Development of animal behavior evaluation method by image analysis
Takahisa Murata (The University of Tokyo)

Pathology of lymphatic vessel/lymphoid tissue-related diseases and its significance as therapeutic targets
Chairs: Masataka Majima (Kitasato Univ, Pharmacol.)
Masanori Hirashima (Niigata University)
Lymphatic vessels in health and disease
Timothy P. Padera (E.L Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, USA)
Neuropeptide CGRP regulates inflammation by increasing lymphangiogenesis
Kanako Hosono (Kitasato University)
Regulation of dermal lymphatic vascular formation by blood vessel-related factors
Masanori Hirashima (Niigata University)

Neuroprotection mediated by promoting glutathione synthesis in the central nervous system
Chairs: Koji Aoyama (Teikyo University)
Suh Sang Won (Dept. Physiol, Coll. Med., Hallym University)
Neuroprotective properties of the excitatory amino acid carrier 1 (EAAC1).
Koji Aoyama (Teikyo University)
The involvement of EAAC1 in diurnal variation of ischemic Zn2+ toxicity
Youichirou Higashi (Kochi University)
EAAC1 gene deletion reduces adult hippocampal neurogenesis after transient cerebral ischemia
Suh Sang Won (Department of Physiology, College of Medicine, Hallym University)
Glutathione in astrocytes as a target of neuroprotection
Masato Asanuma (Okayama University)

Shedding light on brain functions and novel therapeutic strategies by multi-scale calcium signal analysis
Chairs: Sho Kakizawa (Kyoto University)
Kaoru Sato (National Institute of Health Sciences)
Double-Nanodomain Coupling of P/Q-type Ca2+ Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing
Tomohiko Irie (National Institute of Health Sciences)
Multiscale Ca2+ imaging for brain function analysis
Makoto Osanai (Osaka University)
Regulation of calcium signal pathway in fear-related memory
Shigeki Moriguchi (Tohoku University)
Involvement of Redox Modification of Ca22+ -Release Channels in Cerebellar Learning and Aging
Sho Kakizawa (Kyoto University)

Cutting-edge of neural circuit research by pharmacology and optogenetics
Chairs: Susumu Jitsuki (Yokohama City University)
Wataru Kakegawa (Keio University)
Projection-identified large-scale recording reveals pathway-specific information outflow from the subiculum
Takuma Kitanishi (Osaka City University)
A novel ligand selectively visualizes and activates chemogenetic receptors in non-human primates
Yuji Nagai (National Institutes for Quantum and Radiological Science and Technology)
Novel optogenetic and chemogenetic tools for understanding of molecular mechanisms which underlie learning and memory.
Wataru Kakegawa (Keio University)
CRMP2 Binding Compound Accelerates Recovery from Central Nervous System damage
Susumu Jitsuki (Yokohama City University)

Frontier in drug discovery targeting nucleic acids
Chairs: Masatoshi Hagiwara (Kyoto University)
Kazuhiko Nakatani (Osaka University)
Drug Discovery for Genetic Diseases Caused by Aberrant mRNA Splicing
Masatoshi Hagiwara (Kyoto University)
Regulation of higher order structures and function of RNA by RNA-binding small molecules
Kazuhiko Nakatani (Osaka University)
Pyrrole-Imidazole Polyamides as artificial genetic switches
Hiroshi Sugiyama (Kyoto University)
From the structure analysis of RNA to the identification of novel drug targets
Gota Kawai (Chiba Institute of Technology)

Pharmacology of sleep-wake cycle and circadian clocks
Chairs: Koji L. Ode (The University of Tokyo)
Hiroki R. Ueda (The University of Tokyo / RIKEN)
SIK family regulates sleep/wakefulness in mice
Hiromasa Funato (Toho University)
CaMKII-dependent control of sleep duration in mammals
Koji Ode (The University of Tokyo)
Small molecule modulators of the circadian clock function
Tsuyoshi Hirota (Nagoya University)
Toward clinical application of torpor: active hypometabolism research in mice
Genshiro Sunagawa (RIKEN)

Neuropharmacology of super-rare diseases in the CNS
Chairs: Schuichi Koizumi (University of Yamanashi)
Takeshi Ikeuchi (Niigata University)
Novel therapeutic approach mediated by microglia for rare brain diseases
Takeshi Ikeuchi (Niigata University)
Glial cells and pharmacological targets in Sandhoff disease
Yasuhiro Ogawa (Meiji Pharmaceutical University)
Pathological role of astrocytes in neurodegeneration of multiple sclerosis
Mika Takarada-Iemata (Kanazawa University)
Research on the molecular pathogenesis of “primary astrocyte disorder” Alexander disease.
Kozo Saito (University Yamanashi)

Frontiers in Ca2+ -induced Ca2+release (CICR) research: Commemorating the 50th anniversary of CICR discovery
Chairs: Takashi Murayama (Juntendo University)
Masamitsu Iino (Nihon University)
Our serendipitous encounter with CICR
Makoto Endo (The University of Tokyo)
Analysis of CICR control mechanism using molecular dynamics simulation and malignant hyperthermia model mouse
Toshiko Yamazawa (Jikei University School of Medicine)
Structural insight of Ca2+ induced Ca2+release mechanism revealed by cryo-EM
Haruo Ogawa (The University of Tokyo)
Abnormal RyR2 in arrhythmogenic disorders and CICR
Nagomi Kurebayashi (Juntendo University)

New insight of physiological functions via GPCRs
Chairs: Ikuo Kimura (Tokyo University of Agriculture and Technology)
Daiju Yamazaki (National Institute of Health Sciences)
GPCRs for ketone bodies and energy homeostasis
Junki Miyamoto (Tokyo University of Agriculture and Technology)
Physiological functions of GPCRs sensing Long-chain Free Fatty Acids
Atsuhiko Ichimura (Kyoto University)
Regulation of physiological lipid homeostasis by prostaglandin receptor
Tomoaki Inazumi (Kumamoto University)
V1b vasopressin receptor accelerates interaction between β-arrestin and μ-type opioid receptor and enhances opioid tolerance and adenylate cyclase sensitization
Taka-aki Koshimizu (Jichi Medical University)

Novel pharmacological approaches in search of therapeutic targets for psychiatric and neurological disorders: Challenges and opportunities
Chairs: Mitsuhiko Yamada (National Center of Neurology and Psychiatry)
Youichirou Higashi (Kochi University)
Optogenetic examination of effects of stress on the orbitofrontal-amygdala synaptic transmission
Hiroshi Kuniishi (National Center of Neurology and Psychiatry)
Mechanism of axonal degeneration: from molecular signaling to the development of therapeutic applications
Toshiyuki Araki (National Center of Neurology and Psychiatry)
Novel defense strategy against progressive neurodegeneration by controlling intracellular Zn2+ dysregulation
Atsushi Takeda (University of Shizuoka)
Therapeutic strategy for Parkinson’s disease: Targeting zinc-binding protein in astrocytes
Ikuko Miyazaki (Okayama University)
Neuroimmune system associated with brain development and neurodevelopmental disorders
Shogo Tanabe (National Center of Neurology and Psychiatry)

Multiple organ interactions associated with dysfunction and restoration of tissue homeostasis in response to pathological and psychological stress
Chairs: Takuya Sasaki (The University of Tokyo)
Shiho Kitaoka (Kobe University)
Iron metabolism disturbance induced by repeated social defeat stress
Shiho Kitaoka (Kobe University)
Involvement of gut microbiome in the behavioral abnormality by early weaning
Kazutaka Mogi (Azabu University)
Anlaysis of multiple organ interactions by recordings and manipulations of vagus nerve spiking activity
Takuya Sasaki (The University of Tokyo)
Vagal nerve signal-regulated cell proliferation for maintaining whole body homeostasis
Junta Imai (Tohoku University)

Promotion of Strategic Academia Drug Discovery through the Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS) Program
Chairs: Kazutake Tsujikawa (Lab. Cell. Physiol., Grad. Sch. Pharm. Sci., Osaka University)
Masaru Tanokura (Grad. Sch. Agric. Life Sci., University of Tokyo)
Development of a novel peroxisome proliferator-activated receptor alpha activator to treat nonalcoholic steatohepatitis
Keisuke Tachibana (Osaka University)
Application for drug discovery using mammalian artificial chromosomes
Yasuhiro Kazuki (Tottori University)
Cardiovascular Safety Tests for the Promotion of Drug Development in Academia
Atsuhiko Naito (Toho University)
Academic drug discovery with pharmaceutical modality in Center for Research and Education on Drug Discovery of Hokkaido University
Katsumi Maenaka (Hokkaido University)

The ideal pain control -Novel findings making a breakthrough in opioid analgesics-
Chairs: Norikazu Kiguchi (Wakayama Medical University)
Wakako Fujita (Nagasaki University)
Current status and issues in clinical use of opioids: expectations for development of novel analgesics
Takayuki Nakagawa (Kyoto University Hospital)
Further classification of μ-opioid analgesics based on “intracellular biased-signaling through μ-opioid receptors”
Naoko Kuzumaki (Hoshi University)
MOPr-DOPr heteromer: The meaning and possibility as novel therapeutic target for pain control
Wakako Fujita (Nagasaki University)
Safe opioid analgesics targeting nociceptin receptor in primates
Norikazu Kiguchi (Wakayama Medical University)

Frontiers in drug discovery targeting the ubiquitin-proteasome system
Chairs: Yuhei Nishimura (Mie University)
Mikihiko Naito (National Institute of Health Sciences)
The role of primary cilium in cell growth and differentiation
Masaki Inagaki (Mie University)
An investigation of the role of the ubiquitin-proteasome system using zebrafish
Yuhei Nishimura (Mie University)
Drug discovery of small molecule modulators for ubiquitin-proteasome system with in silico screening strategy, INTENDD
Hirotsugu Komatsu (Interprotein Corporation)
Ubiquitin-proteasome drug development with SNIPER technology
Mikihiko Naito (National Institute of Health Sciences)

Novel therapeutic strategies for the fibrosis of circulatory diseases
Chairs: Aya Yamamura (Aichi Medical University)
Masanari Umemura (Yokohama City University)
Doxorubicin induces trans-differentiation in cardiac fibroblasts via cell death-independent pathways
Masanari Umemura (Yokohama City University)
The roles of gap junctional intercellular communication in non-alcoholic steatohepatitis (NASH) and liver fibrosis
Aya Naiki-Ito (Nagoya City University)
exploring mechanisms of renal fibrosis progression
Daisuke Nakano (Kagawa University)
Vascular remodeling in pulmonary arterial hypertension: roles of CaSR and PDGF
Aya Yamamura (Aichi Medical University)

Recent findings related to regulation of homeostasis by neural and endocrinological networks
Chairs: Licht Miyamoto (Tokushima University)
Hiroko Ikeda (Hoshi University)
The role of central nervous system in the regulation of glucose homeostasis
Hiroko Ikeda (Hoshi University)
MicroRNAs 106b and 222 improve hyperglycemia in a mouse model of insulin-deficient diabetes via pancreatic β-cell proliferation
Tetsuya Yamada (Tokyo Medical and Dental University)
High Phosphate diet affects the regulation of endocrine FGFs functions.
Hiroshi Kurosu (Jichi Medical University)
Regulation of glucagon secretion and pharmacotherapy for diabetes
Licht Miyamoto (Tokushima University)

Neuroimmune crosstalk and pain
Chairs: Atsufumi Kawabata (Kindai University)
Gerald W Zamponi (Dept. Physiol. Pharmacol., Cumming Sch. Med, University Calgary)
Regulation of pain signaling by the innate immune system
Gerald W Zamponi (Dept Physiol Pharmacol, Cumming School of Medicine , University of Calgary)
The role of meningeal mast cells in ATP-induced nociceptive firing in trigeminal afferents. Anti-nociceptive effects of hydrogen sulfide
Guzel Sitdikova (Dept of Human and Anim Physiol, Inst of Fundamental Med and Biol, Kazan Federal Univ, Kazan, Russia)
Brain-immune system and its maintenance of brain pain memory in fibromyalgia
Hiroshi Ueda (Kyoto University)
Neuroimmune crosstalk in neuropathic and visceral pain: HMGB1 and ATP as key mediators
Atsufumi Kawabata (Kindai University)

Abnormal cell differentiation and neural diseases
Chairs: Minoru Narita (Hoshi University)
Satoshi Imai (Kyoto University Hospital)
Abnormal cell differentiation of human microglial cells and neuropsychiatric disorders: Translational research using human induced microglia-like (iMG) cells
Takahiro A. Kato (Kyushu University)
Dedifferentiation of Schwann cells by taxanes participates in the chemotherapy-induced peripheral neuropathy pathogenesis
Satoshi Imai (Kyoto University Hospital)
Dynamic change in brain-microenvironment along with epigenetic modulation by exposure to stress
Minoru Narita (Hoshi University)

Chronic inflammation – novel mechanism and drug development
Chairs: Hiroyuki Takano (Chiba University)
Ichiro Manabe (Chiba University)
Coordinated regulation of lipid metabolism and inflammatory response in macrophages
Yumiko Oishi (Nippon Medical School)
Immuneregulation and tissue repair by Ym1+ monocytes
Kenichi Asano (Tokyo University of Pharmacy and Life Sciences)
Cross-talking between EMT and inflammatory responses
Noritaka Yamaguchi (Chiba University)
Systemic environment regulates central nervous system regeneration
Rieko Muramatsu (National Center of Neurology and Psychiatry)

Breakthrough in GPCR research and new insights of drug targets
Chairs: Taka-aki Koshimizu (Jichi Medical University)
Hitoshi Kurose (Kyushu University)
Overview of recent GPCR research
Hitoshi Kurose (Kyushu University)
Shedding light on complexity of G-protein coupling by large-scale functional assays
Asuka Inoue (Tohoku University)
Time-resolved Conformational Analysis during GPCR-Gs Coupling
Ka Young Chung (School of Pharmacy, Sungkyunkwan University, Republic of Korea)
TAK-071, a novel M1 positive allosteric modulator with low cooperativity, improves cognitive function in rodents with few cholinergic side effects
Haruhide Kimura (Takeda Pharmaceutical Company Limited)
Development of protein-ligand binding prediction method by deep learning
Masakazu Sekijima (Tokyo Institute of Technology)

Recent advances towards pharmacological and toxicological applications of human induced pluripotent stem cells
Chairs: Yasunari Kanda (National Institute of Health Sciences)
Junko Kurokawa (University of Shizuoka)
Current status and future perspectives in cardiovascular and neural toxicity testing using human iPSC technology
Yasunari Kanda (National Institute of Health Sciences)
Analysis of contractile functions of human iPS-derived cardiomyocytes using motion field imaging
Junko Kurokawa (University of Shizuoka)
High throughput screening in silico via computer models of induced-pluripotent stem cell derived cardiomyocytes
Colleen Clancy (Department of Physiology and Membrane Biology, Department of Pharmacology, School of Medicine, University of California Davis)
Personalized medicine diagnostics for cardiac safety
Ksenia Blinova (US FDA, CDRH/OSEL/DBP iPSC&EP lab)
Modeling of psychiatric disorders using iPSC technology
Takanobu Nakazawa (Osaka University)

Exploring novel targets for antidepressant development in terms of mechanisms of actions of existing drugs
Chairs: Mitsuhiro Yoshioka (Hokkaido University)
Makoto Kondo (Osaka University)
Serotonergic activation and antidepressant-like effects
Yu Ohmura (Hokkaido University)
Novel mode of antidepressant action based on exercise-induced beneficial effects
Makoto Kondo (Osaka University)
Role of prefrontal VEGF signaling in the rapid antidepressant actions of ketamine
Satoshi Deyama (Kanazawa University)
Looking into glial power in regulation of mood disorders
Yihui Cui (Center for Neuroscience, School of Medicine, Zhejiang University)

Molecular mechanisms and therapeutic strategies for muscle atrophy
Chairs: Yuji Hara (Kyoto University)
Motohiro Nishida (National Institutes of Natural Sciences)
Myocardial atrophy regulated by the formation of TRPC3 protein complex
Motohiro Nishida (National Institutes of Natural Sciences)
Interstitial mesenchymal progenitors are crucial for homeostatic skeletal muscle integrity
Akiyoshi Uezumi (Tokyo Metropolitan Institute of Gerontology)
A system for evaluating the contractile force of myotubes, and drug discovery applications
Yasuko Manabe (Tokyo Metropolitan University)
Role of mechanosensing machinery in muscle regeneration
Yuji Hara (Kyoto University)

Frontiers in cancer therapy
Chairs: Masahiro Nishibori (Okayama University)
Akira Nishiyama (Kagawa University)
Development of antibody-drug conjugates that target vascular endothelial cells to promote anti-tumor activity
Shangze Gao (Okayama University)
S100A8/A9 and its novel receptors play a critical part in organ tropic cancer metastasis
Masakiyo Sakaguchi (Okayama University)
Development of anti-cancer agent targeting on (pro)renin receptor
Akira Nishiyama (Kagawa University)

Recent topics in neuropharmacological research on the pathogenesis of stress-related diseases
Chair: Takahiro Shimizu (Kochi University)
Neural mechanisms involved in the physical stress-induced inhibition of ovarian function
Fusako Kagitani (University of Human Arts and Sciences)
The function of intracellular muscarinic acetylcholine receptor: influence of physiological stress
Takayoshi Masuoka (Kanazawa Medical University)
Potential involvement of the mitochondrial unfolded protein response in depressive-like symptoms in mice
Yuki Kambe (Kagoshima University)
Central regulation mechanisms for brain nicotinic acetylcholine receptor-mediated activation of the sympatho-adrenomedullary outflow
Takahiro Shimizu (Kochi University)

Recent advances in respiratory disease research
Chairs: Masato Tsutsui (Ryukyu University)
Yumiko Imai (National Institutes of Biomedical Innovation, Health and Nutrition)
Diverse roles of nitric oxide synthases in the pathogenesis of lung diseases
Masato Tsutsui (Ryukyu University)
Pharmacological aspects of Respiratory Diseases
Kazuhiro Yatera (University of Occupational and Environmental Health)
Pathological mechanisms and novel therapeutic outlooks for sepsis-associated acute lung injury
Yuichi Hattori (Health Sciences University of Hokkaido)
Role of neuropeptides in lung
Yumiko Imai (National Institutes of Biomedical Innovation, Health and Nutrition)

Novel therapy for allergic diseases targeting hyperresponsiveness
Chairs: Osamu Kaminuma (Hiroshima University)
Mayumi Saeki (Tokyo Metropolitan Institute of Medical Science)
Requirement for neuropeptide Y in the development of allergen-induced airway hyperresponsiveness and inflammation
Nobuaki Miyahara (Okayama University)
Non-coding RNAs and bronchial smooth muscle hyperresponsiveness in allergic bronchial asthma
Yoshihiko Chiba (Hoshi University)
Th9 cells elicit bronchial hyperresponsiveness through eosinophil-independent mechanisms
Mayumi Saeki (Tokyo Metropolitan Institute of Medical Science)
Th2 cells induce nasal type-1-hypersensitivity-like reaction in mice.
Naruhito Iwasaki (Osaka City University)

Young Scientist Career Building Support Program
(Supported by Association of Next Generation Scientists in JPS)

1.Student Sessions

March 16 (Mon) 4:50 pm – 7:20 pm Room C-G

2.Career Design Seminar+Round-table Talk

March 16 (Mon) 7:20 pm – 8:00 pm Room F

Takeshi Takarada (Okayama University)
Chiaki Kuriyama (Mitsubishi Tanabe Pharma)

3.Networking Event

March 16 (Mon) 8:00 pm – 9:00 pm Room B

Pharmacology Research and Technology Seminar

General Session (Oral/Poster), Annual Best Presentation Award Candidates’ Oral Session

Technical Presentation

体内埋め込み型実験動物生体情報取得システム
Jun Shibuya (HIKARIDENSHI CO., LTD.)
CSTジャパン 若手向け技術セミナー
Yuri Koda (Cell Signaling Technology Japan, K.K.)
ナニオン テクノロジーズ ジャパン社の新製品のご紹介
Mitsuyoshi Shimane (Nanion Technologies Japan K.K.)
深部で様々な測定が可能なファイバーフォトメトリーの現状と可能性
Yuji Koumura (Lucir Inc.)

Open Innovation Drug Discovery

Poster presentation by several companies will be run at the buffet-style banquet room.
March 17 (Tue) 6:30 pm – 8:30 pm
Queen’s Grand Ballroom, B2F, West Wing, The Yokohama Bay Hotel Tokyu

Luncheon Seminar/Exhibition

LS-1 Luncheon Seminar 1

Chair: Takeshi Kaneko(Professor and Chairman, Department of Pulmonology Yokohama City University Graduate School of Medicine)
Takahiko Horiguchi(”Department of Respiratory Medicine Ⅱ, Fujita Health University School of Medicine Director of General Allergy Center)

LS-2 Luncheon Seminar 2

Chair: Hitoshi Hashimoto(Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University)
Takashi Yoshio(Department of Clinical Pharmacy Faculty of Pharmaceutical Sciences, Toho University)

LS-3 Luncheon Seminar 3

Chair: Tatsuya Zenkoh (Manager, Division of Drug Research, Department of Innovative Drug Discovery and Development, AMED)
Introduction of BINDS for Drug Discovery and Life Science Research
Yukiko Oura(Deputy Manager, Division of Drug Research, Department of Innovative Drug Discovery and Development, AMED)
Development of cancer immunotherapy by using human iPSC-derived NKT cells
Haruhiko Koseki(Deputy Director, RIKEN Center for Integrative Medical Sciences/BINDS Program Officer)

LS-4 Luncheon Seminar 4

Chair: Naohiko Anzai(Department of Pharmacology, Chiba University Graduate School of Medicine)
Atsushi Nakajima(Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine)

LS-5 Luncheon Seminar 5

Chair: Kazumi Nishijima(Visiting Professor of Yokohama City University, Fellow of Clinical Development Planning Management, Mochida Pharmaceutical Co., LTD.)
Shiho Ogawa(Director, JEM Utilization Center)
Izumi Yoshizaki(JAXA Protein Crystal Growth Project Manager, JEM Utilization Center)
Dai Shiba(Manager for JAXA Rodent Research, JEM Utilization Center)

LS-6 Luncheon Seminar 6

Chair: Akira Nishiyama(Department of Pharmacology, Kagawa University Medical School, Japan)
Kimiyoshi Ichida(Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences)

LS-7 Luncheon Seminar 7

Chair: Hirofumi Kai(Kumamoto University Faculty of Life Sciences Department of Molecular Medicine)
Masanori Sasaki(Sapporo Medical University Research Institute for Frontier Medicine Department of Neural Regenerative Medicine)

LS-8 Luncheon Seminar 8

Chair: Manabu Morimoto(Kanagawa Cancer Center)
Akito Nozaki(Yokohama City University Medical Center)

Diversity Promotion Seminar (Luncheon Seminar)

LS-9 Luncheon Seminar 9 Let’s think about “generation gap”

最近、上司と部下のコミュニケーションの難しさがよく話題になりますが、世代間のコミュニケーションギャップは、研究の場でもあるのではないでしょうか。
そこで、今回の薬理学会ダイバーシティー推進セミナーは、「世代間ギャップ」をテーマといたしました。
セミナーでは、昨年に続き、薬理学会でご活躍の先生方から世代間ギャップに関して日頃感じていることを交えながらご自身のワークライフバランスなどをご紹介いただき、ご参加の皆様と「世代間ギャップ」について考える時間にしたいと思います。

Chair: Kumiko Ishige (Laboratory of Pharmacology, School of Pharmacy, NihonUniversity)
Hiroko Ikeda (Department of Pathophysiology and Therapeutics, Hoshi University School of Pharmacy and Pharmaceutical Sciences)
Taka-aki Koshimizu (Division of Molecular Pharmacology, Department of Pharmacology,Jichi Medical University)
Hiroko Okutsu (Candidate Discovery Science Labs., Astellas Pharma Inc.)
Yoshihisa Ito (Pharmacy Education Center, Yokohama University of Pharmacy)

Ebashi Setsuro Award Lecture

シナプスと核を結ぶ活動依存的神経可塑性メカニズムの解明と応用
Haruhiko Bito (The University of Tokyo)

The Encouragement of Young Investigator Award Lecture

精神・神経変性疾患の病態形成に関与する脳内炎症および疾患モデル細胞を用いた創薬に関する研究
Shiho Kataoka (Kobe University)
レゾルビン類の抗うつ作用の機序解明と創薬応用に向けた薬理学的研究
Satoshi Deyama (Kanazawa University)
食物アレルギーにおけるPGD2の役割解明と治療,診断への応用
Tatsuro Nakamura (The University of Tokyo)

Joint Symposia

PS-CNPHARS Joint Session –
Current Status of Pharmacological Research in Japan and China
Chairs: Masamitsu Iino (Nihon University)
Guanhua DU (Institute of Materia Medica, Chinese Academy of Medical Sciences;
Former President of Chinese Pharmacological Society)
Activation of certain serotonergic pathways exerts antidepressant-like effects
Mitsuhiro Yoshioka (Hokkaido University)
Pharmacological and new drug studies on traditional Chinese medicine
Yongxiang Zhang (Beijing Institute of Pharmacology and Toxicology; President of Chinese Pharmacological Society)
Studies on the histaminergic neuron system by using the knockout mice and positron emission tomography in collaboration with Chinese fellows
Kazuhiko Yanai (Tohoku University)
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors
Meiyu Geng (Shanghai Institute of Materia Medica, Chinese Academy of Sciences)

The Japanese Medical Science Federation – Deep brain stimulation: the importance of interdisciplinary studies and fostering young researchers
Chairs: Takashi Sakurai (Juntendo University)
Shigeo Okabe (The University of Tokyo)
神経内科領域におけるDBSの位置づけと課題
Ryosuke Takahashi (Kyoto University)
Deep Brain Stimulation for Parkinson’s Disease
Atsushi Umemura (Juntendo University)
DBS – from a viewpoint of system neurophysiologist
Atsushi Nambu (National Institutes of Natural Sciences)
Medical student training program for medical research – programs and efforts in the University of Tokyo
Shigeo Okabe (The University of Tokyo)
DBS: From the point of view of glial functions
Schuichi Koizumi (University Yamanashi)

The Physiological Society of Japan – Multifaceted approaches to elucidate the mechanisms of psychiatric disorders.
Chairs: Ryuta Koyama (The University of Tokyo)
Tomoyuki Miyazaki (Yokohama City University)
Possible role of microglia in mental disorder-related hearing impairment
Ryuta Koyama (The University of Tokyo)
Pharmacological approach to overcome schizophrenia
Taku Nagai (Nagoya University)
Chronic stress causes excessive aggression by altering synaptic actin dynamics in the mPFC.
Hirobumi Tada (National Center for Geriatrics and Gerontology)
Mechanisms underlying the development of mental disorders revealed using novel PET tracer recognizing AMPA receptors
Tomoyuki Miyazaki (Yokohama City University)

The Japanese Society of Clinical Pharmacology and Therapeutics – Basic and Clinical Pharmacology on the Single Stage
Chairs: Hiroshi Watanabe (Hamamatsu University School of Medicine)
Mitsuhiro Yoshioka (Hokkaido University)
First-in-Human (FIH) to Proof-of-Concept (PoC) studies in Japan for early access of pharmaceuticals for patients around the world, even at an international pharmaceutical company
Masako Nakano (Novartis Pharma K.K.)
Development and induction of the new human study program as an item in pharmacologic exercise for medical students.
Naoki Uchida (Showa University)
Pharmacological approach and diagnosis for Alport syndrome
Hirofumi Kai (Kumamoto University)
Transporter inhibitors: from target identification and pharmacology to clinical development
Yoshikatsu Kanai (Osaka University)

Society for Clinical Epidemiology – Evaluation of drug safety and efficacy by clinical epidemiology utilizing large scale medical databases including real world data
Chairs: Koji Kawakami (Kyoto University)
Satoshi Asai (Nihon University)

Japanese Association for Experimental Animal Technologists– Technique succession of animal experiments on pharmacological research and practice
Chairs: Wada Koichiro (Shimane University)
Naohiko Anzai (Chiba University)
Toward the creation of a researcher database and succession of research techniques: From the first questionnaire survey
Naohiko Anzai (Chiba University)
Pharmacological training with small animals in Kochi University
Motoaki Saito (Kochi University)
Efforts by The Japanese Association for Experimental Animal Technologists (JAEAT) : Scheduled technical training courses and their future development
Norio Yata (Okayama University)

JPS Satellite Symposium

Development of “phenomics analysis for next generation” by stem cell and iPS cell researches

Chairs: Naoko Kuzumaki (Hoshi University)
Takanobu Nakazawa (Osaka University)
Accurate modeling of neurodevelopmental disorders using patients’-derived iPS cells
Takanobu Nakazawa (Osaka University)
Reverse translational neuroscience research to unravel the causes of intractable diseases
Naoko Kuzumaki (Hoshi University)
Unveiling the impact of epigenetic regulation in disease pathogenesis with iPS cell technology
Yamada Yasuhiro (The University of Tokyo)
Regenerative Medicine and Drug Development using Stem Cells
Hideyuki Okano (Keio University)

Morning Seminar

Morning Seminar 1:A microsensing system using needle-type of boron-doped diamond microsensor for the in vivo real-time drug monitoring

Genki Ogata(Niigata University)

Morning Seminar 2:Viral vectors for manipulation and recording of neural activity

Kazuki Nagayasu(Kyoto University)

Morning Seminar 3:Development of non-invasive drug and biomedicine delivery technologies based on the physiological nose-to-brain routes

Takanori Kanazawa(Nihon University)

Open Seminar

その1 臨床医のための薬理学シンポジウム「糖尿病治療薬ワークショップ」
March 15 (Sun) 10:30~12:30Hamagin Hall VIA MARE
Chairs: Hitoshi Ando (Kanazawa University)
Toshiyuki Sasaguri (Kyushu University)
糖尿病の臨床像と治療の現状 ―総合診療医の立場から
Mitsuyasu Ohta (Yokohama City University)
糖尿病治療法に関する臨床エビデンスー糖尿病専門医の立場から
Yasuo Terauchi (Yokohama City University)
医学生が選んだ糖尿病のパーソナル・ドラッグ
Toshiyuki Sasaguri (Kyushu University)
非専門医も知っておくべき糖尿病治療薬:医学部で学ぶべき薬は何か
Hitoshi Ando (Kanazawa University)
糖尿病の薬物治療に関する研究の動向
Chihiro Yabe (Kyoto Prefectural University of Medicine)

その2 スポーツとくすりと認知症の予防に向けて
March 15 (Sun) 14:00~16:00Hamagin Hall VIA MARE
Chair: Atsushi Sugiyama (Toho University)

【Special Program】

いきいきアクティブに!運動とくすりの上手な付き合い方
Kakuko Nakamura(Orthopedist, Sports doctor)

【Educational Lectures】

メタボリックシンドローム・認知症とスポーツ
Toshimasa Yamauchi (The University of Tokyo Hospital)
高血圧・動脈硬化とスポーツ
Shinji Takai (Osaka Medical College)

Company-Organized Symposia1

AI and big data in the life science field: Activity in the Life Intelligence Consortium

Organizers: Yasushi Okuno (Kyoto University)
Hiroki Shirai (Astellas Pharma Inc.)
AI創薬コンソーシアムLINCの紹介
Yasushi Okuno (Kyoto University)
AI for Nephrology Using Electronic Medical Records
Eiichiro Uchino (Kyoto University)
Application of artificial intelligence for drug repositioning
Hiroaki Iwata (Kyoto University)
Towards a system combining ADMET prediction AI and de novo structure generation AI
Teruki Honma (RIKEN)
JDream Expert Finder: A Search Engine to Find Young Promising Researchers
Hiroto Inoue (Tokyo Denki University)

Company-Organized Symposia2

Acceleration of Investigator initiated clinical trials: Recent activities

Organizers: Yuichi Tomura (Astellas Pharma Inc.)
Kohei Kikkawa (Mitsubishi Tanabe Pharma Corporation)
Current status of drug development in academia
Koji Ikeda (Tohoku University Hospital)
Acceleration of TR from basic science to clinical trial at the iACT
Eriko Sumi (Kyoto University Hospital)
Investigator-initiated clinical trial of an anti-cancer drug targeted on LAT1
Hayato Hikita (Osaka University)
Investigator-Initiated Clinical Trial of HGF Plasmid Product
Tetsuya Ishihama (AnGes Inc.)

Young Scientists Symposium

Young Researchers Career Support Program

Pharmacology Education

For future laboratory exercises in pharmacology

Chairs: Chihiro Yabe (Kyoto Prefectural University of Medicine)
Masaki Mogi (Ehime University)
An encouragement of role-play ~ the utility of student-centered physician-patient role-play for practical pharmacotherapy education ~
Toshihiko Yanagita (University of Miyazaki)
Pharmacokinetic training of aspirin for medical undergraduate students to understand the concept of ion trap
Takeya Sato (Tohoku University)
Laboratory practice of pharmacology for medical students to learn pathophysiological science
Atsushi Sugiyama (Toho University)
Activity of the consortium of pharmacological training in Chugoku-Shikoku region
Masaki Mogi (Ehime University)